Actor Eric Dane, best known for his roles in TV series Grey's Anatomy and Euphoria, has died aged 53.
His representatives said he died from amyotrophic lateral sclerosis (ALS), known also as Lou Gehrig's disease.
Dane announced his diagnosis last year, and had become an advocate for ALS awareness before his death.
"He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the centre of his world," said a statement.
Described as "determined to make a difference for others" with the disease, his representatives said he would be "lovingly remembered" and "deeply missed".
"Eric adored his fans and is forever grateful for the outpouring of love and support he's received," they added.
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Dane starred in ABC medical drama Grey's Anatomy from 2006 until 2012, and reprised his role in 2021. He was also celebrated for his part in HBO's Euphoria.
Other appearances included Saved By The Bell, Gideon's Crossing, Marley & Me, and X-Men: The Last Stand.
He was married to Rebecca Gayheart, a fellow actor and model.
His memoir is due to be published later this year.
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